Charles Bevins

Charles Bevins

Position Title
Professor

Unit
Medical Microbiology and Immunology, School of Medicine


Bio

 Research

  • Characterization of Antimicrobial Peptides from Human and Rodent Mucosal Tissues
  • Study of the Regulated Expression and Processing of Antimicrobial Peptides
  • In vivo models of defensin activity
  • Altered Expression of Antimicrobial Peptides in Inflammatory Bowel Disease, Otitis Media, and Necrotizing Enterocolitis

Selected publications

  1. Clevers, HC and Bevins, CLPaneth cells: maestros of the small intestinal cryptsAnnu Rev Physiol 75: 289-311, 2013.
  2. Chu, H, Pazgier, M, Jung, G, Nuccio, S-P, Castillo, PA, de Jong, MF, Winter, MG, Winter, SE, Wehkamp, J, Shen, B, Salzman NH, Underwood, MA, Tsolis, RM, Young, GM, Lu, W, Lehrer, RI, Bäumler, AJ, and Bevins, CLHuman α-defensin 6 promotes mucosal innate immunity through assembled peptide nanonetsScience 337:477-481, 2012.
  3. Tollner TL, Bevins CL, Cherr GN: Multifunctional glycoprotein DEFB126-a curious story of defensin-clad spermatozoaNat Rev Urol. 9:365-375, 2012.
  4. Tollner, TL, Venners, SA, Hollox, EJ, Yudin, AI, Liu, X, Tang, G, Xing, H, Kays, RJ, Lau, T, Overstreet,, JW, Xu, X, Bevins, CL*, Cherr, GN*: A common mutation in DEFB126 causes impaired sperm function and subfertilityScience Transl Med 3: 92ra65, 2011. (equal contributors)
  5. Bevins, CL and Salzman, NH: The potter’s wheel: The host’s role in sculpting its microbiotaCell Mol Life Sci68:3675-3685, 2011.
  6. Bevins, CL and Salzmann NH: Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasisNat. Reviews Microbiol. 9: 356-368, 2011.
  7. Winter, SE, Thiennimitr, P, Winter, MG, Butler, BP, Huseby, DL, Crawford, RW, Russell, JM, Bevins, CL, Adams, LG, Tsolis, RM, Roth, JR, and Bäumler, AJ. Gut inflammation provides a respiratory electron acceptor for SalmonellaNature 467:426-429, 2010
  8. Biswas, A, Liu, Y-J, Hao, L, Mizoguchi, A, Salzman, NH, Bevins, CL, and Kobayashi, KS Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileumProc. Natl. Acad. Sci. 107:14739-44, 2010
  9. Bevins, CL and Liu, F-T A sweet target for innate immunityNat. Medicine 16: 263-264, 2010.
  10. Salzman, NH, Hung, K, Haribhai, D, Chu, H, Karlsson-Sjöberg, J, Amir, E, Teggatz, P, Barman, M, Hayward, M, Eastwood, D, Stoel, M, Zhou, Y, Sodergren, E, Weinstock, GM, Bevins, CL, Williams, C and Bos, NA: Enteric defensins are essential regulators of intestinal microbial ecologyNat Immunol 11: 76-82, 2010
  11. Raffatellu, M, George, MD, Akiyama, Y, Hornsby, MJ, Nuccio, SP, Paixao, TA, Butler, BP, Chu, H, Santos, RL, Berger, T, Mak, TW, Tsolis, RM, Bevins, CL, Solnick, JV, Dandekar, S, and Baumler, AJ: Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestineCell Host Microbe 5: 476-86, 2009.
  12. Mukherjee, S, Partch, CL, Lehotzky, RE, Whitham, CV, Chu, H, Bevins, CL, Gardner, KH, and Hooper, LV: Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegmentJ Biol Chem 284:4881-8, 2009.
  13. Yudin, AI, Tollner, TL, Treece, CA, Kays, RJ, Cherr, GN, Overstreet, JW, Bevins, CLBeta-defensin 22 is a major component of the mouse sperm glycocalyxReproduction 136:753-65, 2008.
  14. Hornsby, MJ, Huff, JL, Kays, RJ, Canfield, DR, Bevins, CL and Solnick, JV Helicobacter pylori induces an antimicrobial host response in rhesus macaques in a Cag Pathogenicity Island-Dependent MannerGastroenterology 134:1049-1057, 2008.
  15. Bevins, CL and Liu, F-T Rosacea: Skin innate immunity gone awry? Nat. Medicine 13: 904-905, 2007
  16. Baumgarth, N and Bevins, CL, Skin deep but complexNature 449:551-553, 2007.
  17. Wehkamp, J, Wang, G, Kubler, I, Schaeffeler, E, Nuding, S, Gregorieff, A, Schnabel, Kays, RJ, Reinisch, W, Teml,, A, Vermeire, S, Rutgeerts, P, Fellermann, K, Burk, O, Clevers, H, Schwab, M, Bevins, CL and Stange, EF. The Paneth Cell alpha-Defensin Deficiency of Ileal Crohn's Disease is Linked to Wnt/Tcf-4. J. Immunol. 179:3109-3118, 2007.
  18. McGillivary, G., Ray, W.C., Bevins, C.L., Munson Jr., R.S., Bakaletz, L.O., A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis mediaMolec. Immunol. 44: 2446-2458, 2007.
  19. Salzmann, NH, Underwood, MA, and Bevins CLPaneth Cells, Defensins, and the Commensal Microbiota: A hypothesis on intimate interplay at the intestinal mucosaSeminars in Immunology 19: 70-83, 2007.

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